Mechanism Guide
Interactive guide to the 41 therapeutic mechanisms across 9 goalsThis guide follows the current mechanism rulebooks. Scored means the mechanism can be assessed when its required evidence is resolved; it may still be rejected or halted for a particular target. Design outputs include experimental candidates, retrieved sequences, and construct templates. They require experimental validation.
Therapeutic Goals
Make or increase
Produce, replace or increase useful RNA or protein.
Reduce
Reduce harmful RNA, protein production or toxic RNA activity.
Modify or correct
Change RNA sequence, processing, isoforms or molecular interactions; expression direction can depend on context.
Platform Overview
Select a Therapeutic Goal
Choose a therapeutic goal from the left panel to explore the mechanisms available for that objective. Each goal contains mechanisms that can be assessed when their prerequisites are resolved, and qualitative flags. Design availability does not establish activity or safety.