{
  "status": "Qualified for research-only calibration reanalysis; not independent base-model validation",
  "primaryMFASSRows": 27733,
  "missingGeneMetadataRows": 77,
  "publishedScoreSubset": 8324,
  "scores": {
    "S0": {
      "available": 8297,
      "unscored": 27,
      "reasons": {
        "no annotated gene overlapping the variant": 4,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x134169750>": 3,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x1336c4210>": 3,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x134180f50>": 2,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x1332b4650>": 2,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x13381c290>": 2,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x133401f90>": 2,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x13368ead0>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x132cb1190>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x133974050>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x13339ab50>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x133932d90>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x133679790>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x1336e28d0>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x133496950>": 1,
        "skipped by SpliceAI: Skipping record (ref issue): <__main__._Record object at 0x1336c6f50>": 1
      }
    },
    "P0": {
      "available": 8297,
      "unscored": 27,
      "reasons": {
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 1974] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4225] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 7480] WARNING, skipping variant: Variant not contained in a gene body. Do GTF/FASTA chromosome names match?": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 7479] WARNING, skipping variant: Variant not contained in a gene body. Do GTF/FASTA chromosome names match?": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 7478] WARNING, skipping variant: Variant not contained in a gene body. Do GTF/FASTA chromosome names match?": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4233] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4232] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4231] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4230] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4229] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4228] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4227] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4226] WARNING, skipping variant: Mismatch between FASTA (ref base: T) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4224] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 1975] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4223] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4222] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4221] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4220] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4219] WARNING, skipping variant: Mismatch between FASTA (ref base: T) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4218] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4217] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4216] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4215] WARNING, skipping variant: Mismatch between FASTA (ref base: C) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4214] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 4213] WARNING, skipping variant: Mismatch between FASTA (ref base: G) and variant file (ref base: <withheld>).": 1,
        "skipped by Pangolin (no gene, ref mismatch or unsupported): [Line 7481] WARNING, skipping variant: Variant not contained in a gene body. Do GTF/FASTA chromosome names match?": 1
      }
    }
  },
  "localClinVarRowsAudited": 137,
  "exactVariantOverlaps": 0,
  "positionOverlaps": 0,
  "geneOverlapRows": 20,
  "geneOverlapSymbols": [
    "DMD"
  ],
  "eligibleRows": 8262,
  "uniqueVariants": 8262,
  "groups": 460,
  "partitions": {
    "development": {
      "rows": 6128,
      "groups": 327
    },
    "test": {
      "rows": 2134,
      "groups": 133
    }
  },
  "reporterAlleleChecksPassed": 27733,
  "baseModelTrainingOverlap": "Not ruled out: local site calibration uses GENCODE chr22; base networks trained on genomic splicing. Gene/variant overlap audit covers the local 137-SNV delta calibrator, not all upstream training.",
  "scoreInputContract": "Published GENCODE44 canonical unmasked delta within 50nt; differs from deployed M3 sequence-window contract.",
  "sources": {
    "assay": "https://github.com/KosuriLab/MFASS",
    "scores": "https://github.com/rewire-bio/rewire-benchmarks/tree/779eeb5c88712442fbc9682c3d417cb7a7427fe3/benchmarks/mfass/results/matched-annotation-v1"
  },
  "hashes": {
    "qualified-inputs.csv": "08557265d924fd384e97eaa7ccf22b77122777e7924ff1a85411c721d6e6b7bf",
    "outcomes.csv": "1ad6ce084b69d601b2e4221efec95a57cfc3c193715092b2e35e3e26462ef013",
    "delta_calibration_data_clinvar.parquet": "448f251f86a0974098da86b822c1ac76c71464d589c290a5e68a3944d4891371",
    "delta_calibration_models.pkl": "205b8bfc7d3830194c27da9e8ddd18aefaa0643f1da446135656a7fcc39be775"
  }
}